In this study, the experts showed that intense tumor cells, melanoma particularly, can handle responding to microenvironmental factors and also influencing other cells via epigenetic mechanisms, an excellent referred to as bi-directional cellular communication. Bi-directional cellular conversation is essential to both tumor progression and embryological development. The significance of the research team’s finding can be profound in that it implies that through secretion of Nodal, intense melanoma cells maintain their plasticity and modulate the microenvironment, as exemplified by their capability to direct the formation of zebrafish cells.‘Everyone can get behind ending AIDS, but this statement doesn’t really tell us how to do this.’ Still, UNAIDS insisted in its report that people are at the ‘beginning of the end of the AIDS epidemic’ and said the global outbreak could be stopped by 2030. But with no millions and vaccine of individuals having the virus or getting newly infected, some researchers said ending HIV could be idealistic rather than practical. ‘We’ve made progress, however the amount of people getting infected is still extraordinarily high,’ said Shabbar Jaffar, a professor of epidemiology at the London College of Tropical and Hygiene Medicine.