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Once again, low-risk children had the reverse design, in keeping with the OFC having a regulatory function in monitoring reward values in mentally healthy people. The united team did not find altered connectivity between your OFC and other, predetermined cerebral regions of interest, however. All privileges reserved. Neither of the parties endorse or recommend any commercial products, services, or equipment.. Aberrant reward processing more likely to precede bipolar symptom onset By Eleanor McDermid, Senior medwireNews Reporter Healthy children who have a mother or father with bipolar disorder display altered brain activation during prize processing, research shows. Weighed against children without Axis I psychiatric disorders amongst their first – or second-degree relatives, children of bipolar patients had changed function in the pregenual cingulate when anticipating a reward and in the orbitofrontal cortex when gaining or failing to gain an incentive.