Low degrees of energetic CREB or of neuropeptide Y correlate with symptoms of anxiousness and excessive alcohol usage, the researchers showed in a prior study. In the present study, mice that acquired only one duplicate of the CREB gene – – healthy mice have two copies – – created lower-than-normal levels of the CREB proteins, neuropeptide Y and another substance in the brain associated with alcoholic beverages drinking . The mice consumed about 50 % more alcohol than normal littermates and demonstrated higher baseline anxiety-like behaviors, as measured by a maze test. Alcohol exposure reduced their anxiousness, though less so than in normal mice, and increased degrees of active CREB proteins and neuropeptide Y in parts of the amygdala, the certain section of the brain associated with emotion, fear and anxiety.Infected mice that inhaled aerosolized nanoparticles encapsulating silver carbene complexes , a novel course of silver-structured antimicrobials with broad-spectrum activity, showed a significant survival benefit over the control mice that received nanoparticles without the SCCs. Treated mice also had decreased lung bacterial burden and spread, compared to the control mice. Moreover, the treatment with nanoparticles occurred once a day every, a regimen that is known to increase compliance in human patients, versus the most common dosing interval of inhaled antibiotics for P.