And other developed countries continue steadily to take medicine as directed.

She added that patients should be provided with written, and also oral, instructions for medication and that doctors should inform family of the prescribed program to make sure that patient follow it. ‘Adherence is an enormous problem, costing billions of dollars,’ Papaioannou said, adding, ‘Obviously, unless you take the drug, you won’t have the full benefit’ . This article is republished with kind permission from our friends at the The Kaiser Family Foundation.Furthermore, tBX6 missense was identified by us mutations in 7 of 161 persons with congenital scoliosis in series 1, a prevalence greater than that among the handles and among Han Chinese populations in Beijing and in southern China in the 1000 Genomes Project .22 In a combined evaluation, the association of TBX6 missense mutations with congenital scoliosis was significant . Because missense mutations could possibly be benign or also confer an increase of function, we did not include them in additional analyses, although we can not exclude the possibility of a role for them in congenital scoliosis.