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‘ Calif. Report reveals ‘nontoxic’ nail polishes could cause birth defects Dibutyl phthalate originates from the category of phthalates, a classification of compounds known to be disrupt function of the endocrine system, Dr. Kenneth R. Spaeth, the director of the Occupational and Environmental Medication Center’s Department of Population Wellness at North Shore University Medical center in Manhasset, N.Y., told HealthPop. Phthalates can transform hormone levels or disrupt the way the body handles its response to hormones. Although studies about the toxin are latest relatively, it has been known to trigger birth defects, including developmental and neurological concerns in fetuses. ‘In a fetus, there’s felt to be greater susceptibility to the consequences,’ Spaeth said.