: Detection of Blast-Related Traumatic Brain Injury in U.

Brody, M.D., Ph.D.: Detection of Blast-Related Traumatic Brain Injury in U.S. Military Personnel In the current wars in Afghanistan and Iraq, the number of blast-related traumatic brain injuries may be as high as 320,000.3,4 No individual autopsy studies conducted with the use of current immunohistochemical methods5,6 have been published.7,8 Computer simulations of the effects of blast-induced pressure waves on the mind claim that coup and contrecoup regions could be at the mercy of high stresses.9,10 Simulations also claim that the orbitofrontal regions and the posterior fossa may sustain intense stresses independently of the subject’s head orientation in accordance with the blast.10 Findings that are in keeping with this view add a positron-emission tomographic research showing decreased cerebellar basal glucose metabolism11 and a case statement documenting a lesion in cerebellar white matter on MRI after blast injury.12 In a swine model of experimental blast damage, traumatic axonal injury in several regions, including cerebellar tracts, was detected.13 We therefore hypothesized that traumatic axonal injury is a principal feature of human being blast-related traumatic brain injury.There are currently no effective treatment options for patients with HCV genotype 2 or 3 3 infection who don’t have a sustained virologic response with the existing standard of care of 24 weeks of treatment with peginterferon and ribavirin and for those who have medical contraindications to interferon therapy or decide against it. Our findings claim that 12 weeks of treatment with sofosbuvir and ribavirin can be an effective option for individuals with HCV genotype 2 infection. However, for patients with genotype 3 disease, particularly anyone who has cirrhosis or who’ve not had a response to prior treatment with interferon, extending the duration of treatment to 16 weeks may provide an additional benefit.