Previously scientists had to separate the cell types from a mixture prior to analysis to verify that actual changes had occurred in gene expression but. Is is time consuming and expensive and requires large samples of blood, adds Dr click to follow .
To overcome these obstacles, developed the study team a computational approach called cell specific significance analysis of microarrays . What does csSAM, to marry to marry the concepts of cell separation with the ease of analyzing large families of genes on a microarray, explains Dr. Using a mathematical approach, we can virtually separate the different cell types found in blood, determine the gene expression patterns of these cell types, and identify, the changes in gene expression are based on the actual disease and simply due to variations in the cell are proportions. .
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