Additional key exclusion requirements are listed in Section C in the Supplementary Appendix. Study Protocol After a screening period, eligible patients were randomly assigned in a 3:2 ratio to get 150 mg of nintedanib twice daily or placebo for 52 weeks. An interactive telephone and Web-based response system was used to perform randomization. Patients, investigators, and the study sponsor were unacquainted with the study-group assignments through the entire study. Completion of the 52-week treatment period was accompanied by a follow-up check out 4 weeks later. Spirometric assessments were executed at baseline; at 2, 4, 6, 12, 24, 36, and 52 weeks; and at the follow-up visit.This acne device heats skin up to 120 degrees for approximately two minutes. The heat shall not hurt epidermis, but it will leave a little red mark for approximately 20 minutes. Zeno can be used up to three times a full day using one pimple. Zeno acne gadget ranges in cost from $89.00 – $200.00 also to substitute a cartridge costs $25.00 to $55.00. ThermaClear Acne Treatment Device FDA-cleared, the ThermaClear cordless device uses heat to clear acne.