Man hearts, in response to ischemia and reperfusion-induced cardiac damage in animals subjected to prenatal nicotine treatment. Additional study is hence required.. 11 % of American women smoke during pregnancy At least 11 % of American women smoke during pregnancy. The negative effects of nicotine contact with their fetuses and newborns are significant. A 2004 survey by the Doctor General, for example, discovered that females who smoked during pregnancy acquired children who had been at a 3 x higher risk for SIDS than had been the offspring of non-smokers. Now, a new research using laboratory rats, provides strong evidence that the consequences of maternal smoking through the prenatal period of life can result in cardiac vascular dysfunction beyond the formative years – – and into adulthood.We believe that by to be able to correct what’s considered to be a critical pathophysiological defect in PAH, reduced expression of prostaglandin synthase namely, we may get the chance to fundamentally transformation the course of PAH. We further believe that the ‘second era’ rational nature of Intrexon’s genetic engineering technology provides the enabling technology necessary to make this goal a practical actuality for PAH sufferers. We are pleased to be dealing with Intrexon in this interesting and potentially disease changing collaboration,’ stated James S. Kuo, M.D., M.B.A., CEO of Adeona. We are impressed with Adeona’s demonstrated ability to operate effectively and decisively and we believe these characteristics will serve both parties well as we navigate through the drug development process and commercialization,’ stated Glenn Nedwin, President, Individual Therapeutics Division at Intrexon.