Major adrenal insufficiency: – In this case, Addison’s disease occurs due to harm to endocrine cortex. As a result, it cannot make adrenocortical hormones in adequate levels. Because of this, body’s own immune system begins to attack many organs in your body. It can assault and destroy endocrine cortex causing further complications also. 2. Secondary endocrine insufficiency: – In cases like this, Adrenal insufficiency occurs due to harm to pituitary gland. Pituitary gland creates a hormone known as adrenocorticotropic hormone . It works as a stimulator for the creation of endocrine cortex hormones. If ACTH creation is reduced, endocrine hormones are also not secreted in sufficient quantities even if endocrine glands are intact.Heard said that in the entire case of a Caesarean two operations would need to be performed. ‘This lady was extremely lucky,’ said Khalaf. On Friday however the Southwest News Agency based in Filton Kersey was not immediately available for comment, England, said it had bought the privileges to her story. It could not disclose the amount.. Adding AKT inhibitors to radiotherapy could possibly be effective for treating many cancers Cancer Research UK researchers can see how giving a course of medications called AKT inhibitors in conjunction with radiotherapy might increase its effectiveness across a wide range of cancers, regarding to a scholarly research published in the Journal of Scientific Investigation today*.